HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: VDR (P11473)
Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)
Gene: VDR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25910212
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 427
+	Hs
		504101 HSP7C_HUMAN (1-646): 0: 967: 100.00		NR1I3_HUMAN (17-421): 5.58e-108: 324: 33.66
+	Hs
		564076 HSP76_HUMAN (6-646): 0: 955: 77.54		NR1I3_HUMAN (17-421): 5.58e-108: 324: 33.66
+	Hs
		503668 HSP7C_HUMAN (1-646): 0: 967: 100.00		NR2C2_HUMAN (16-427): 7.44e-97: 303: 19.71
+	Hs
		503572 HSP7C_HUMAN (1-646): 0: 967: 100.00		PPARG_HUMAN (11-424): 5.91e-96: 298: 25.60
+	Hs
		871570 HSP72_HUMAN (2-646): 0: 940: 85.47		NR1I3_HUMAN (17-421): 5.58e-108: 324: 33.66
+	Hs
		368878 HSP7C_HUMAN (1-646): 0: 967: 100.00		ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74
+	Hs
		369084 HS71L_HUMAN (2-646): 0: 966: 82.48		ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74
+	Hs
		504003 HSP7C_HUMAN (1-646): 0: 967: 100.00		NR1H3_HUMAN (2-425): 7.16e-95: 294: 29.60
+	Hs
		564024 HSP76_HUMAN (6-646): 0: 955: 77.54		PPARG_HUMAN (11-424): 5.91e-96: 298: 25.60
+	Hs
		368938 HSP76_HUMAN (6-646): 0: 955: 77.54		ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74
+	Hs
		503444 HSP7C_HUMAN (1-646): 0: 967: 100.00		NR4A1_HUMAN (8-426): 5.04e-88: 280: 21.00
+	Hs
		320162 HSP7C_HUMAN (1-646): 0: 967: 100.00		ERR2_HUMAN (8-426): 3.98e-88: 276: 20.53
+	Dm
		505049 HSP7D_DROME (1-612): 0: 938: 86.60		ECR_DROME (14-425): 2.04e-93: 301: 28.09
+	Hs
		487886 HSP7C_HUMAN (1-646): 0: 967: 100.00		RARA_HUMAN (22-424): 1.18e-85: 270: 23.33
+	Hs
		369248 HSP72_HUMAN (2-646): 0: 940: 85.47		ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74
+	Mm
		509285 HS71B_MOUSE (1-646): 0: 957: 83.90		RARA_MOUSE (4-424): 1.01e-87: 275: 21.43