HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: HSP76 (P17066)
Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6)
Gene: HSPA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

The method score is based on:

Property	Details
Experiments	29568061, 34349018, unassigned1655
Identification Methods	affinity chromatography technology, cross-linking study, pull down
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HSP70~HSP70
Common GO terms	GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol and 16 others more... GO:0005886 - plasma membrane GO:0006986 - response to unfolded protein GO:0016887 - ATP hydrolysis activity GO:0019899 - enzyme binding GO:0031072 - heat shock protein binding GO:0031625 - ubiquitin protein ligase binding GO:0034605 - cellular response to heat GO:0034774 - secretory granule lumen GO:0042026 - protein refolding GO:0044183 - protein folding chaperone GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding GO:0070062 - extracellular exosome GO:0072562 - blood microparticle GO:0140662 - ATP-dependent protein folding chaperone GO:1904813 - ficolin-1-rich granule lumen
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	646
Hs

1	643

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024