HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	33961781, 27684187, 31501420, 38223760
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0032570 - response to progesterone
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 504
+	Hs
		125115 HSP7C_HUMAN (1-646): 0: 967: 100.00		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		504580 HSP7C_HUMAN (1-646): 0: 967: 100.00		ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17
+	Hs
		504792 HSP7C_HUMAN (1-646): 0: 967: 100.00		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		713923 HS71L_HUMAN (2-646): 0: 966: 82.48		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		564032 HSP76_HUMAN (6-646): 0: 955: 77.54		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		808427 HSP72_HUMAN (2-646): 0: 940: 85.47		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		564179 HSP76_HUMAN (6-646): 0: 955: 77.54		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		504871 HSP7C_HUMAN (1-646): 0: 967: 100.00		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61