HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	27684187, 17979178
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005770 - late endosome GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0005925 - focal adhesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 393
+	Hs
		503561 HSP7C_HUMAN (1-646): 0: 967: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		503460 HSP7C_HUMAN (1-646): 0: 967: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		503528 HSP7C_HUMAN (1-646): 0: 967: 100.00		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		503902 HSP7C_HUMAN (1-646): 0: 967: 100.00		CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81
+	Hs
		713942 HS71L_HUMAN (2-646): 0: 966: 82.48		CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81
+	Hs
		564016 HSP76_HUMAN (6-646): 0: 955: 77.54		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		483778 HS71B_HUMAN (1-646): 0: 948: 84.37		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		503996 HSP7C_HUMAN (1-646): 0: 967: 100.00		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		734898 HSP72_HUMAN (2-646): 0: 940: 85.47		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		713953 HS71L_HUMAN (2-646): 0: 966: 82.48		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		564065 HSP76_HUMAN (6-646): 0: 955: 77.54		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	At
		612295 HS701_ARATH (3-646): 0: 944: 76.35		CDKA1_ARATH (65-364): 1.03e-114: 337: 23.78
+	Hs
		871550 HSP72_HUMAN (2-646): 0: 940: 85.47		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		504010 HSP7C_HUMAN (1-646): 0: 967: 100.00		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	Hs
		564067 HSP76_HUMAN (6-646): 0: 955: 77.54		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	Hs
		503636 HSP7C_HUMAN (1-646): 0: 967: 100.00		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Hs
		564030 HSP76_HUMAN (6-646): 0: 955: 77.54		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69