HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19233847
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0032570 - response to progesterone GO:0098978 - glutamatergic synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 875
+	Hs
		871538 HSP72_HUMAN (2-646): 0: 940: 85.47		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		125115 HSP7C_HUMAN (1-646): 0: 967: 100.00		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		504580 HSP7C_HUMAN (1-646): 0: 967: 100.00		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		504920 HSP7C_HUMAN (1-646): 0: 967: 100.00		HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20
+	Hs
		504792 HSP7C_HUMAN (1-646): 0: 967: 100.00		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		504222 HSP7C_HUMAN (1-646): 0: 967: 100.00		HECD2_HUMAN (141-874): 1.13e-174: 526: 28.33
+	Hs
		504318 HSP7C_HUMAN (1-646): 0: 967: 100.00		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97