HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	26657153, 23386615
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0006606 - protein import into nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 487
+	Hs
		713953 HS71L_HUMAN (2-646): 0: 966: 82.48		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		564065 HSP76_HUMAN (6-646): 0: 955: 77.54		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		871550 HSP72_HUMAN (2-646): 0: 940: 85.47		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		504007 HSP7C_HUMAN (1-646): 0: 967: 100.00		PAK1_HUMAN (3-305): 1.66e-117: 357: 40.91
+	Hs
		564066 HSP76_HUMAN (6-646): 0: 955: 77.54		PAK1_HUMAN (3-305): 1.66e-117: 357: 40.91
+	Hs
		871553 HSP72_HUMAN (2-646): 0: 940: 85.47		PAK2_HUMAN (8-300): 1.44e-118: 359: 40.26
+	Hs
		871551 HSP72_HUMAN (2-646): 0: 940: 85.47		PAK1_HUMAN (3-305): 1.66e-117: 357: 40.91
+	Ce
		450535 HSP1_CAEEL (1-646): 0: 937: 84.39		MIG15_CAEEL (14-408): 7.26e-76: 259: 37.62