HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: NR1H3 (Q13133)
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
Gene: NR1H3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032570 - response to progesterone
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 447
+	Hs
		368878 HSP7C_HUMAN (1-646): 0: 967: 100.00		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		369084 HS71L_HUMAN (2-646): 0: 966: 82.48		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		320162 HSP7C_HUMAN (1-646): 0: 967: 100.00		ERR2_HUMAN (9-446): 3.62e-117: 351: 25.23
+	Hs
		368938 HSP76_HUMAN (6-646): 0: 955: 77.54		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		487886 HSP7C_HUMAN (1-646): 0: 967: 100.00		RARA_HUMAN (15-447): 1.17e-111: 338: 29.00
+	Hs
		503572 HSP7C_HUMAN (1-646): 0: 967: 100.00		PPARG_HUMAN (69-443): 3.18e-108: 330: 27.64
+	Hs
		503327 HSP7C_HUMAN (1-646): 0: 967: 100.00		VDR_HUMAN (95-446): 9.2e-109: 329: 32.21
+	Mm
		509285 HS71B_MOUSE (1-646): 0: 957: 83.90		RARA_MOUSE (15-447): 9.18e-112: 338: 29.00
+	Hs
		369248 HSP72_HUMAN (2-646): 0: 940: 85.47		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		503444 HSP7C_HUMAN (1-646): 0: 967: 100.00		NR4A1_HUMAN (4-443): 9.26e-103: 319: 27.25
+	Hs
		564024 HSP76_HUMAN (6-646): 0: 955: 77.54		PPARG_HUMAN (69-443): 3.18e-108: 330: 27.64
+	Hs
		504498 HSP7C_HUMAN (1-646): 0: 967: 100.00		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		714036 HS71L_HUMAN (2-646): 0: 966: 82.48		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		564142 HSP76_HUMAN (6-646): 0: 955: 77.54		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Dm
		505049 HSP7D_DROME (1-612): 0: 938: 86.60		ECR_DROME (42-446): 2.28e-100: 320: 36.73
+	Hs
		504101 HSP7C_HUMAN (1-646): 0: 967: 100.00		NR1I3_HUMAN (98-442): 2.14e-50: 176: 32.58
+	Hs
		564076 HSP76_HUMAN (6-646): 0: 955: 77.54		NR1I3_HUMAN (98-442): 2.14e-50: 176: 32.58
+	Hs
		871570 HSP72_HUMAN (2-646): 0: 940: 85.47		NR1I3_HUMAN (98-442): 2.14e-50: 176: 32.58