HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: PAK1 (Q13153)
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
Gene: PAK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, 32687490, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0005925 - focal adhesion
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 545
+	Hs
		564066 HSP76_HUMAN (6-646): 0: 955: 77.54		PAK1_HUMAN (1-545): 0: 558: 100.00
+	Hs
		871551 HSP72_HUMAN (2-646): 0: 940: 85.47		PAK1_HUMAN (1-545): 0: 558: 100.00
+	Hs
		871553 HSP72_HUMAN (2-646): 0: 940: 85.47		PAK2_HUMAN (1-544): 2.14e-168: 489: 74.82
+	Hs
		503528 HSP7C_HUMAN (1-646): 0: 967: 100.00		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		564016 HSP76_HUMAN (6-646): 0: 955: 77.54		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		503996 HSP7C_HUMAN (1-646): 0: 967: 100.00		STK4_HUMAN (247-545): 2.66e-127: 382: 41.20
+	Hs
		713953 HS71L_HUMAN (2-646): 0: 966: 82.48		STK4_HUMAN (247-545): 2.66e-127: 382: 41.20
+	Hs
		564065 HSP76_HUMAN (6-646): 0: 955: 77.54		STK4_HUMAN (247-545): 2.66e-127: 382: 41.20
+	Hs
		871550 HSP72_HUMAN (2-646): 0: 940: 85.47		STK4_HUMAN (247-545): 2.66e-127: 382: 41.20