HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: SIM2 (Q14190)
Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)
Gene: SIM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 667
+	Hs
		504148 HSP7C_HUMAN (1-646): 0: 967: 100.00		HIF1A_HUMAN (2-501): 2.75e-126: 395: 32.11
+	Hs
		713985 HS71L_HUMAN (2-646): 0: 966: 82.48		HIF1A_HUMAN (2-501): 2.75e-126: 395: 32.11
+	Mm
		571858 HS71B_MOUSE (1-646): 0: 957: 83.90		HIF1A_MOUSE (2-525): 3.97e-129: 403: 31.11
+	Hs
		503482 HSP7C_HUMAN (1-646): 0: 967: 100.00		ARNT_HUMAN (2-576): 5.63e-105: 338: 16.72
+	Hs
		504638 HSP7C_HUMAN (1-646): 0: 967: 100.00		NPAS1_HUMAN (2-494): 3.68e-101: 322: 31.60
+	Hs
		649072 HSP72_HUMAN (2-646): 0: 940: 85.47		ARNT_HUMAN (2-576): 5.63e-105: 338: 16.72
+	Hs
		503558 HSP7C_HUMAN (1-646): 0: 967: 100.00		AHR_HUMAN (5-518): 5.16e-91: 303: 20.04
+	Hs
		871577 HSP72_HUMAN (2-646): 0: 940: 85.47		NCOA2_HUMAN (4-657): 9.63e-92: 313: 17.13