HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: IKBB (Q15653)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Gene: NFKBIB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 356
+	Hs
		713979 HS71L_HUMAN (2-646): 0: 966: 82.48		IKBB_HUMAN (1-356): 9.91e-80: 249: 100.00
+	Hs
		503471 HSP7C_HUMAN (1-646): 0: 967: 100.00		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Hs
		639682 HS71L_HUMAN (2-646): 0: 966: 82.48		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Hs
		503906 HSP7C_HUMAN (1-646): 0: 967: 100.00		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Mm
		926175 HSP7C_MOUSE (1-646): 0: 967: 99.85		IKBA_MOUSE (7-335): 8.92e-77: 240: 31.07
+	Hs
		713945 HS71L_HUMAN (2-646): 0: 966: 82.48		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Hs
		564057 HSP76_HUMAN (6-646): 0: 955: 77.54		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Hs
		121564 HSP7C_HUMAN (1-646): 0: 967: 100.00		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Hs
		121572 HS71L_HUMAN (2-646): 0: 966: 82.48		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Hs
		503916 HSP7C_HUMAN (1-646): 0: 967: 100.00		ANK2_HUMAN (159-346): 4.02e-39: 150: 17.55
+	Hs
		714021 HS71L_HUMAN (2-646): 0: 966: 82.48		ANKK1_HUMAN (163-348): 2.22e-38: 147: 20.00
+	Hs
		483759 HS71A_HUMAN (1-646): 0: 948: 84.37		ANK2_HUMAN (159-346): 4.02e-39: 150: 17.55
+	Hs
		504882 HSP7C_HUMAN (1-646): 0: 967: 100.00		RAI14_HUMAN (94-266): 8.7e-11: 65.5: 27.17
+	Hs
		503415 HSP7C_HUMAN (1-646): 0: 967: 100.00		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Hs
		504362 HSP7C_HUMAN (1-646): 0: 967: 100.00		ANKH1_HUMAN (6-91): 2.81e-10: 63.8: 16.28
+	Hs
		587444 HS71L_HUMAN (2-646): 0: 966: 82.48		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Hs
		564002 HSP76_HUMAN (6-646): 0: 955: 77.54		BCL3_HUMAN (49-151): 2.25e-12: 69.8: 28.16
+	Mm
		638457 HS71A_MOUSE (1-646): 0: 954: 83.59		NFKB1_MOUSE (14-140): 5.94e-11: 65.9: 29.46
+	Hs
		564000 HSP76_HUMAN (6-646): 0: 955: 77.54		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Hs
		587480 HSP72_HUMAN (2-646): 0: 940: 85.47		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57