HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	34642328, 21145461
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 81
+	Hs
		474905 HSP7C_HUMAN (1-646): 0: 967: 100.00		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		713983 HS71L_HUMAN (2-646): 0: 966: 82.48		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Dm
		505044 HSP7D_DROME (1-612): 0: 938: 86.60		RS27A_DROME (1-77): 3.39e-36: 121: 57.14
+	Hs
		564084 HSP76_HUMAN (6-646): 0: 955: 77.54		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Ce
		450538 HSP1_CAEEL (1-646): 0: 937: 84.39		NEDD8_CAEEL (1-77): 7.56e-34: 112: 87.01