HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16497536
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 731
+	Hs
		564131 HSP76_HUMAN (6-646): 0: 955: 77.54		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		871685 HSP72_HUMAN (2-646): 0: 940: 85.47		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		504523 HSP7C_HUMAN (1-646): 0: 967: 100.00		FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15
+	Hs
		504412 HSP7C_HUMAN (1-646): 0: 967: 100.00		POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94
+	Hs
		714020 HS71L_HUMAN (2-646): 0: 966: 82.48		POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94
+	Hs
		564125 HSP76_HUMAN (6-646): 0: 955: 77.54		POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94
+	Hs
		504344 HSP7C_HUMAN (1-646): 0: 967: 100.00		WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79
+	Hs
		503614 HSP7C_HUMAN (1-646): 0: 967: 100.00		LIS1_HUMAN (509-730): 2.11e-55: 197: 21.24
+	Hs
		503817 HSP7C_HUMAN (1-646): 0: 967: 100.00		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Ce
		450531 HSP1_CAEEL (1-646): 0: 937: 84.39		LIN53_CAEEL (552-730): 5.7e-14: 76.7: 16.75