HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: MT21A (Q8WXB1)
Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A)
Gene: METTL21A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	26186194, 28514442, 26115316, 33961781, 23349634
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031072 - heat shock protein binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 218
+	Hs
		714031 HS71L_HUMAN (2-646): 0: 966: 82.48		MT21A_HUMAN (1-218): 2.1e-77: 233: 100.00
+	Hs
		483797 HS71B_HUMAN (1-646): 0: 948: 84.37		MT21A_HUMAN (1-218): 2.1e-77: 233: 100.00
+	Hs
		871699 HSP72_HUMAN (2-646): 0: 940: 85.47		MT21A_HUMAN (1-218): 2.1e-77: 233: 100.00
+	Hs
		504537 HSP7C_HUMAN (1-646): 0: 967: 100.00		EFMT3_HUMAN (13-216): 3.92e-64: 200: 42.51
+	Hs
		714042 HS71L_HUMAN (2-646): 0: 966: 82.48		EFMT3_HUMAN (13-216): 3.92e-64: 200: 42.51
+	Hs
		504229 HSP7C_HUMAN (1-646): 0: 967: 100.00		MT21C_HUMAN (21-212): 2.38e-55: 179: 31.98
+	Hs
		713993 HS71L_HUMAN (2-646): 0: 966: 82.48		MT21C_HUMAN (21-212): 2.38e-55: 179: 31.98
+	Hs
		871718 HSP72_HUMAN (2-646): 0: 940: 85.47		EFMT3_HUMAN (13-216): 3.92e-64: 200: 42.51
+	Hs
		504315 HSP7C_HUMAN (1-646): 0: 967: 100.00		CMKMT_HUMAN (32-218): 1.04e-47: 160: 19.07
+	Hs
		504677 HSP7C_HUMAN (1-646): 0: 967: 100.00		MET22_HUMAN (7-200): 7.21e-40: 142: 21.36
+	Hs
		714062 HS71L_HUMAN (2-646): 0: 966: 82.48		MET22_HUMAN (7-200): 7.21e-40: 142: 21.36
+	Hs
		504646 HSP7C_HUMAN (1-646): 0: 967: 100.00		ANM1_HUMAN (57-208): 1.75e-33: 125: 16.03
+	Hs
		504370 HSP7C_HUMAN (1-646): 0: 967: 100.00		ETKMT_HUMAN (44-176): 3.41e-28: 108: 22.96
+	Hs
		871737 HSP72_HUMAN (2-646): 0: 940: 85.47		ANM6_HUMAN (57-197): 2e-32: 122: 16.03