HitPredict

Interactor 1: HSP7D (P11147)
Heat shock 70 kDa protein cognate 4 (Heat shock 70 kDa protein 88E)
Gene: Hsc70-4

Interactor 2: DNAJ1 (Q24133)
DnaJ protein homolog 1 (DROJ1)
Gene: DnaJ-1

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	27984043, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005829 - cytosol GO:0051085 - chaperone cofactor-dependent protein refolding GO:0051087 - protein-folding chaperone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Dm			1 334
+	Hs
		279280 HS71L_HUMAN (2-651): 0: 966: 79.54		DNJB5_HUMAN (1-333): 1.05e-123: 360: 50.43
+	Hs
		714088 HS71L_HUMAN (2-651): 0: 966: 79.54		DNJB4_HUMAN (1-333): 6.56e-124: 360: 53.25
+	Hs
		279272 HSP7C_HUMAN (1-651): 0: 959: 84.03		DNJB5_HUMAN (1-333): 1.05e-123: 360: 50.43
+	Hs
		504901 HSP7C_HUMAN (1-651): 0: 959: 84.03		DNJB4_HUMAN (1-333): 6.56e-124: 360: 53.25
+	Hs
		636256 HS71L_HUMAN (2-651): 0: 966: 79.54		DNJB1_HUMAN (1-333): 5.29e-121: 353: 49.41
+	Hs
		279274 HSP76_HUMAN (2-651): 0: 955: 76.62		DNJB5_HUMAN (1-333): 1.05e-123: 360: 50.43
+	Hs
		503463 HSP7C_HUMAN (1-651): 0: 959: 84.03		DNJB1_HUMAN (1-333): 5.29e-121: 353: 49.41
+	Hs
		564008 HSP76_HUMAN (2-651): 0: 955: 76.62		DNJB1_HUMAN (1-333): 5.29e-121: 353: 49.41
+	Hs
		243312 HS71L_HUMAN (2-651): 0: 966: 79.54		DNJA2_HUMAN (2-334): 2.99e-114: 338: 29.97
+	Hs
		681341 HS71L_HUMAN (2-651): 0: 966: 79.54		DNJA1_HUMAN (5-333): 1.97e-114: 338: 29.94
+	Hs
		243275 HSP7C_HUMAN (1-651): 0: 959: 84.03		DNJA2_HUMAN (2-334): 2.99e-114: 338: 29.97
+	Hs
		503527 HSP7C_HUMAN (1-651): 0: 959: 84.03		DNJA1_HUMAN (5-333): 1.97e-114: 338: 29.94
+	Hs
		243284 HSP76_HUMAN (2-651): 0: 955: 76.62		DNJA2_HUMAN (2-334): 2.99e-114: 338: 29.97
+	Hs
		564015 HSP76_HUMAN (2-651): 0: 955: 76.62		DNJA1_HUMAN (5-333): 1.97e-114: 338: 29.94
+	Hs
		714087 HS71L_HUMAN (2-651): 0: 966: 79.54		DJB11_HUMAN (2-332): 1.08e-103: 309: 30.86
+	Hs
		504897 HSP7C_HUMAN (1-651): 0: 959: 84.03		DJB11_HUMAN (2-332): 1.08e-103: 309: 30.86
+	Hs
		636461 HS71L_HUMAN (2-651): 0: 966: 79.54		DNJB2_HUMAN (5-114): 5.57e-27: 110: 53.45
+	Hs
		504474 HSP7C_HUMAN (1-651): 0: 959: 84.03		DNJB3_HUMAN (4-125): 4.53e-31: 115: 50.79
+	Hs
		503464 HSP7C_HUMAN (1-651): 0: 959: 84.03		DNJB2_HUMAN (5-114): 5.57e-27: 110: 53.45
+	Hs
		564009 HSP76_HUMAN (2-651): 0: 955: 76.62		DNJB2_HUMAN (5-114): 5.57e-27: 110: 53.45