HitPredict

Interactor 1: HSP7D (P11147)
Heat shock 70 kDa protein cognate 4 (Heat shock 70 kDa protein 88E)
Gene: Hsc70-4

Interactor 2: Q9XYW6 (Q9XYW6)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (RING-type E3 ubiquitin transferase CHIP)
Gene: STUB1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ANAPC3~HSP70
Common GO terms	GO:0005737 - cytoplasm GO:0051087 - protein-folding chaperone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Dm			1 289
+	Hs
		714095 HS71L_HUMAN (2-651): 0: 966: 79.54		CHIP_HUMAN (9-289): 9.87e-59: 191: 55.83
+	Mm
		926173 HSP7C_MOUSE (1-651): 0: 959: 84.03		CHIP_MOUSE (9-289): 3e-59: 192: 55.83
+	Hs
		504954 HSP7C_HUMAN (1-651): 0: 959: 84.03		CHIP_HUMAN (9-289): 9.87e-59: 191: 55.83
+	Mm
		571871 HS71B_MOUSE (1-651): 0: 957: 79.42		CHIP_MOUSE (9-289): 3e-59: 192: 55.83
+	Hs
		564209 HSP76_HUMAN (2-651): 0: 955: 76.62		CHIP_HUMAN (9-289): 9.87e-59: 191: 55.83
+	Hs
		503738 HSP7C_HUMAN (1-651): 0: 959: 84.03		PPP5_HUMAN (12-245): 5.33e-33: 128: 19.75
+	Mm
		926131 HSP7C_MOUSE (1-651): 0: 959: 84.03		PPP5_MOUSE (12-245): 4.97e-33: 128: 19.33
+	Hs
		564043 HSP76_HUMAN (2-651): 0: 955: 76.62		PPP5_HUMAN (12-245): 5.33e-33: 128: 19.75
+	Dm
		505082 HSP7D_DROME (1-651): 0: 955: 100.00		Q9V3E9_DROME (9-237): 1.81e-30: 121: 18.22
+	Dm
		505095 HSP7D_DROME (1-651): 0: 955: 100.00		Q9VJD4_DROME (5-220): 1.22e-30: 118: 17.97
+	Hs
		1120567 Q53FA3_HUMAN (2-651): 0: 967: 79.39		DNJC7_HUMAN (18-211): 6.5e-24: 102: 19.60
+	Hs
		714055 HS71L_HUMAN (2-651): 0: 966: 79.54		DNJC7_HUMAN (18-211): 6.5e-24: 102: 19.60
+	Hs
		504631 HSP7C_HUMAN (1-651): 0: 959: 84.03		DNJC7_HUMAN (18-211): 6.5e-24: 102: 19.60
+	Hs
		564188 HSP76_HUMAN (2-651): 0: 955: 76.62		RPAP3_HUMAN (18-135): 1.95e-24: 104: 27.97
+	Hs
		564163 HSP76_HUMAN (2-651): 0: 955: 76.62		DNJC7_HUMAN (18-211): 6.5e-24: 102: 19.60
+	Hs
		483801 HS71B_HUMAN (1-651): 0: 950: 80.18		DNJC7_HUMAN (18-211): 6.5e-24: 102: 19.60
+	Hs
		174578 HSP7C_HUMAN (1-651): 0: 959: 84.03		OGT1_HUMAN (8-255): 9.76e-16: 79.3: 11.69
+	Hs
		213468 HSP7C_HUMAN (1-651): 0: 959: 84.03		SGTA_HUMAN (59-165): 1.01e-09: 60.4: 12.15
+	Hs
		564151 HSP76_HUMAN (2-651): 0: 955: 76.62		SGTB_HUMAN (58-165): 4.53e-11: 64.2: 14.82
+	Mm
		926144 HSP7C_MOUSE (1-651): 0: 959: 84.03		SGTA_MOUSE (59-225): 1.8e-09: 59.6: 10.65