HitPredict

Interactor 1: EGR2 (P11161)
E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (AT591) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20)
Gene: EGR2

Interactor 2: TREF1 (Q96PN7)
Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132)
Gene: TRERF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38297188
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 476 Hs			1 1200
+	Hs
		505239 EGR2_HUMAN (1-476): 0: 567: 100.00		MDEAS_HUMAN (205-1093): 8.2e-54: 207: 26.75
+	Hs
		505258 EGR2_HUMAN (1-476): 0: 567: 100.00		KMT2C_HUMAN (306-789): 7.98e-14: 79: 12.36
+	Hs
		505304 EGR2_HUMAN (1-476): 0: 567: 100.00		CHD7_HUMAN (112-412): 2.75e-09: 64.1: 12.54
+	Hs
		1238812 ZN383_HUMAN (131-310): 2.88e-54: 190: 8.00		RCOR3_HUMAN (781-1154): 1.07e-45: 174: 18.83