HitPredict

Interactor 1: PKHG3 (A1L390)
Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)
Gene: PLEKHG3

Interactor 2: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1219 Hs			1 193
+	Hs
		50573 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		50580 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		50582 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92
+	Hs
		50572 PKHG3_HUMAN (1-1219): 0: 955: 100.00		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		50554 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12
+	Hs
		50579 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		50571 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		925727 PKHG1_HUMAN (45-981): 5.7e-143: 469: 33.61		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		894583 PKHG1_HUMAN (45-981): 5.7e-143: 469: 33.61		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		548672 VAV_HUMAN (3-587): 4.05e-114: 378: 18.38		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		548678 VAV_HUMAN (3-587): 4.05e-114: 378: 18.38		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		548671 VAV_HUMAN (3-587): 4.05e-114: 378: 18.38		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		900768 ARHG2_HUMAN (12-801): 7.51e-109: 367: 12.63		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		156395 RGRF2_HUMAN (12-758): 1.58e-106: 366: 13.29		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		925497 ARHG2_HUMAN (12-801): 7.51e-109: 367: 12.63		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		156397 RGRF2_HUMAN (12-758): 1.58e-106: 366: 13.29		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Mm
		650205 RGRF1_MOUSE (8-760): 1.72e-104: 360: 13.88		RHOA_MOUSE (1-193): 7.11e-82: 242: 92.23
+	Hs
		900679 ARG28_HUMAN (2-911): 5.12e-102: 358: 13.02		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		156394 RGRF2_HUMAN (12-758): 1.58e-106: 366: 13.29		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		915884 ARHG2_HUMAN (12-801): 7.51e-109: 367: 12.63		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82