HitPredict

Interactor 1: PKHG3 (A1L390)
Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)
Gene: PLEKHG3

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32203420, 31871319
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1219 Hs			1 191
+	Hs
		50555 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		50617 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		50580 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		50582 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		50573 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		50554 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		50546 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		50571 PKHG3_HUMAN (1-1219): 0: 955: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		564737 PKHG1_HUMAN (45-981): 5.7e-143: 469: 33.61		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		925727 PKHG1_HUMAN (45-981): 5.7e-143: 469: 33.61		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894583 PKHG1_HUMAN (45-981): 5.7e-143: 469: 33.61		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		548678 VAV_HUMAN (3-587): 4.05e-114: 378: 18.38		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		548671 VAV_HUMAN (3-587): 4.05e-114: 378: 18.38		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		548672 VAV_HUMAN (3-587): 4.05e-114: 378: 18.38		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		925497 ARHG2_HUMAN (12-801): 7.51e-109: 367: 12.63		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		156397 RGRF2_HUMAN (12-758): 1.58e-106: 366: 13.29		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		156394 RGRF2_HUMAN (12-758): 1.58e-106: 366: 13.29		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		900768 ARHG2_HUMAN (12-801): 7.51e-109: 367: 12.63		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		156395 RGRF2_HUMAN (12-758): 1.58e-106: 366: 13.29		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Mm
		650205 RGRF1_MOUSE (8-760): 1.72e-104: 360: 13.88		RHOA_MOUSE (5-191): 9.99e-82: 242: 53.48