HitPredict

Interactor 1: ODB2 (P11182)
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)
Gene: DBT

Interactor 2: SIR4 (Q9Y6E7)
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)
Gene: SIRT4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25525879
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 314
+	Hs
		126290 ODPX_HUMAN (52-477): 3.12e-148: 434: 23.76		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		739369 ODO2_HUMAN (52-481): 3.5e-140: 412: 24.54		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		489844 ODP2_HUMAN (40-137): 9.92e-23: 103: 21.21		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		489826 ODP2_HUMAN (40-137): 9.92e-23: 103: 21.21		SIR3_HUMAN (39-312): 8.61e-87: 267: 27.34
+	Hs
		489825 ODP2_HUMAN (40-137): 9.92e-23: 103: 21.21		SIR7_HUMAN (29-311): 9.49e-74: 234: 26.46