HitPredict

Interactor 1: RALB (P11234)
Ras-related protein Ral-B (EC 3.6.5.2)
Gene: RALB

Interactor 2: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 206 Hs			1 607
+	Xl
		292764 RALBB_XENLA (1-206): 2.81e-91: 267: 94.18		GDS1A_XENLA (1-607): 0: 899: 85.50
+	Hs
		854133 RAB1B_HUMAN (7-204): 1.59e-80: 240: 30.05		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Xl
		292765 RALBA_XENLA (1-206): 1.01e-80: 240: 94.18		GDS1A_XENLA (1-607): 0: 899: 85.50
+	Hs
		854088 RAP1A_HUMAN (15-183): 1e-50: 164: 48.82		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854082 RAP1B_HUMAN (15-193): 4e-50: 162: 47.78		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		349206 RASH_HUMAN (27-181): 3.76e-49: 160: 52.90		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		348587 RASN_HUMAN (27-191): 8.77e-49: 159: 50.00		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		349994 RASK_HUMAN (27-198): 2.81e-47: 155: 50.00		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854086 RRAS2_HUMAN (27-206): 3.88e-46: 152: 46.67		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Dm
		51789 RALA_DROME (13-206): 2.78e-92: 270: 75.26		GDS1_DROME (62-536): 0: 540: 31.27
+	Dm
		51795 Q962I2_DROME (13-186): 1.08e-89: 263: 78.16		GDS1_DROME (62-536): 0: 540: 31.27