HitPredict

Interactor 1: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.864

Property	Details
Experiments	8978305, 10194128, 15143164
Identification Methods	affinity chromatography technology, two hybrid, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C2~SH2, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1271 Hs			1 303
+	Hs
		506541 BCR_HUMAN (1-1271): 0: 1005: 100.00		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		275167 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97
+	Mm
		1144835 BCR_MOUSE (1-1271): 0: 941: 93.79		CRK_MOUSE (3-302): 5.71e-54: 180: 55.21
+	Hs
		506586 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRAP_HUMAN (126-294): 1.63e-24: 100: 19.07
+	Hs
		506565 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Mm
		1141138 BCR_MOUSE (1-1271): 0: 941: 93.79		GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32
+	Hs
		802829 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00
+	Hs
		802581 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		548657 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		548634 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		548630 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10
+	Hs
		924658 FGD6_HUMAN (93-969): 1.47e-86: 311: 14.15		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		1078919 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44
+	Hs
		1078886 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Hs
		924525 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		548628 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86
+	Hs
		1191674 SRGP1_HUMAN (596-1261): 5.55e-75: 273: 14.31		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Mm
		654982 VAV_MOUSE (393-1106): 2.14e-78: 279: 11.78		GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32
+	Hs
		548677 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		924777 Q96D37_HUMAN (393-1092): 1.17e-77: 275: 12.29		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32