HitPredict

Interactor 1: KCC2A (P11275)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: Camk2a

Interactor 2: DCLK2 (Q5MPA9)
Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)
Gene: DCLK2

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30053369
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CaMKII_AD~Pkinase, Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0106310 - protein serine kinase activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 478 Rn			1 767
+	Hs
		1038956 KCC2G_HUMAN (1-475): 0: 617: 71.71		KCC2G_HUMAN (404-748): 1.83e-132: 406: 34.90
+	Hs
		1039048 KCC2G_HUMAN (1-475): 0: 617: 71.71		KCC2A_HUMAN (404-729): 1.25e-131: 401: 37.88
+	Hs
		1038957 KCC2G_HUMAN (1-475): 0: 617: 71.71		KCC2D_HUMAN (404-729): 2.73e-131: 400: 36.67
+	Hs
		1357909 KCC2A_HUMAN (1-478): 0: 569: 99.79		KCC2A_HUMAN (404-729): 1.25e-131: 401: 37.88
+	Hs
		1039197 KCC2A_HUMAN (1-478): 0: 569: 99.79		KCC2D_HUMAN (404-729): 2.73e-131: 400: 36.67
+	Rn
		439486 KCC2A_RAT (1-478): 0: 569: 100.00		KCC2B_RAT (404-753): 1.2e-130: 400: 34.50
+	Mm
		515214 KCC2A_MOUSE (1-478): 0: 569: 100.00		KCC2B_MOUSE (404-753): 1.2e-130: 400: 34.50
+	Hs
		1039054 KCC2D_HUMAN (2-475): 0: 552: 87.55		KCC2D_HUMAN (404-729): 2.73e-131: 400: 36.67
+	Dm
		959115 KCC2A_DROME (2-475): 6.66e-178: 510: 70.74		KCC2A_DROME (404-737): 3.63e-131: 401: 36.84
+	At
		989458 CDPK1_ARATH (5-457): 5.95e-151: 445: 27.61		CDPK1_ARATH (251-761): 9.15e-143: 434: 25.24
+	At
		1105900 CDPKB_ARATH (3-460): 9.23e-154: 448: 30.32		CDPKB_ARATH (387-761): 5.44e-142: 428: 29.77
+	Gm
		1196117 Q84P28_SOYBN (3-404): 6.59e-153: 445: 32.03		Q84P28_SOYBN (393-761): 3.69e-142: 428: 29.79
+	At
		1104924 CDPK4_ARATH (3-460): 7.83e-152: 443: 30.32		CDPK4_ARATH (385-761): 1.62e-140: 424: 29.35
+	At
		989461 CDPK1_ARATH (5-457): 5.95e-151: 445: 27.61		KIN10_ARATH (405-766): 6.88e-132: 402: 30.52
+	Hs
		159170 CSKP_HUMAN (9-307): 2.56e-85: 283: 46.08		KPCI_HUMAN (222-730): 8.44e-139: 423: 18.66