HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: CADH2 (P19022)
Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
Gene: CDH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17005551, 18302981
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 906
+	Hs
		580236 EPHA7_HUMAN (3-783): 0: 629: 19.40		CADH2_HUMAN (1-906): 0: 998: 100.00
+	Hs
		507817 FGFR1_HUMAN (1-822): 0: 861: 100.00		CADH1_HUMAN (26-906): 0: 764: 45.71
+	Hs
		580213 EPHA4_HUMAN (3-783): 0: 620: 19.44		CADH2_HUMAN (1-906): 0: 998: 100.00
+	Hs
		508000 FGFR1_HUMAN (1-822): 0: 861: 100.00		DSC3_HUMAN (5-899): 0: 700: 30.32
+	Hs
		580237 NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08		CADH2_HUMAN (1-906): 0: 998: 100.00
+	Hs
		872427 EPHA5_HUMAN (3-791): 0: 639: 19.15		DSC2_HUMAN (42-899): 0: 710: 30.46
+	Hs
		521744 EPHA2_HUMAN (3-819): 0: 583: 18.68		CADH1_HUMAN (26-906): 0: 764: 45.71
+	Hs
		971014 EPHA7_HUMAN (3-783): 0: 629: 19.40		DSC2_HUMAN (42-899): 0: 710: 30.46
+	Hs
		872632 EPHA4_HUMAN (3-783): 0: 620: 19.44		DSC2_HUMAN (42-899): 0: 710: 30.46
+	Hs
		665215 EPHA2_HUMAN (3-819): 0: 583: 18.68		DSC2_HUMAN (42-899): 0: 710: 30.46
+	Hs
		971016 NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70		DSC2_HUMAN (42-899): 0: 710: 30.46
+	Hs
		507992 FGFR1_HUMAN (1-822): 0: 861: 100.00		DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54
+	Hs
		507929 FGFR1_HUMAN (1-822): 0: 861: 100.00		CAD11_HUMAN (64-599): 3.65e-82: 283: 22.26
+	Hs
		601509 FGFR2_HUMAN (1-821): 0: 803: 71.21		DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54
+	Hs
		607964 FGFR4_HUMAN (29-808): 0: 664: 55.60		DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54
+	Xl
		292719 FGFR1_XENLA (1-822): 0: 780: 77.49		O93264_XENLA (19-372): 1.49e-46: 181: 18.96
+	Hs
		665396 EPHA3_HUMAN (3-775): 0: 643: 19.03		DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54
+	Hs
		872440 EPHA5_HUMAN (3-791): 0: 639: 19.15		DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54
+	Hs
		1048589 EPHA7_HUMAN (3-783): 0: 629: 19.40		DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54
+	Hs
		872645 EPHA4_HUMAN (3-783): 0: 620: 19.44		DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54