HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~fn3, fn3~ig, EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0001501 - skeletal system development GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 976
+	Hs
		507926 FGFR1_HUMAN (1-822): 0: 861: 100.00		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		601465 FGFR2_HUMAN (1-821): 0: 803: 71.21		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		601484 FGFR2_HUMAN (1-821): 0: 803: 71.21		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		609184 FGFR3_HUMAN (6-821): 0: 730: 61.22		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		609225 FGFR3_HUMAN (6-821): 0: 730: 61.22		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		607887 FGFR4_HUMAN (29-808): 0: 664: 55.60		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		607974 FGFR4_HUMAN (29-808): 0: 664: 55.60		EPHA7_HUMAN (4-974): 0: 1128: 50.30
+	Hs
		607929 FGFR4_HUMAN (29-808): 0: 664: 55.60		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		665142 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		665383 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHA5_HUMAN (11-976): 0: 1127: 51.34
+	Hs
		665374 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHB2_HUMAN (28-973): 0: 1089: 48.29
+	Hs
		665384 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHB4_HUMAN (14-970): 0: 986: 44.99
+	Hs
		435514 FGFR1_HUMAN (1-822): 0: 861: 100.00		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		507857 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		601456 FGFR2_HUMAN (1-821): 0: 803: 71.21		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		609173 FGFR3_HUMAN (6-821): 0: 730: 61.22		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		435536 FGFR4_HUMAN (29-808): 0: 664: 55.60		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		433573 FGFR2_HUMAN (1-821): 0: 803: 71.21		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433576 FGFR4_HUMAN (29-808): 0: 664: 55.60		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433602 EPHA3_HUMAN (3-775): 0: 643: 19.03		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91