HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	35384245, 24141780, 33961781, 32707033
Identification Methods	affinity chromatography technology, proximity labelling technology, two hybrid, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0001501 - skeletal system development GO:0005524 - ATP binding GO:0005829 - cytosol GO:0045597 - positive regulation of cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 740
+	Hs
		601482 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		508016 FGFR1_HUMAN (1-822): 0: 861: 100.00		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Rn
		979772 FGFR1_RAT (1-822): 0: 849: 97.69		KS6A1_RAT (1-740): 0: 785: 78.17
+	Hs
		601517 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		609219 FGFR3_HUMAN (6-821): 0: 730: 61.22		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		607926 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		607975 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		608180 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A6_HUMAN (1-740): 0: 771: 76.54
+	Hs
		384525 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		507876 FGFR1_HUMAN (1-822): 0: 861: 100.00		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		507838 FGFR1_HUMAN (1-822): 0: 861: 100.00		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		384892 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		508015 FGFR1_HUMAN (1-822): 0: 861: 100.00		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02
+	Hs
		434163 RET_HUMAN (384-774): 2.63e-98: 332: 45.77		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		601516 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02
+	Hs
		607895 FGFR4_HUMAN (29-808): 0: 664: 55.60		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		665151 EPHA2_HUMAN (3-819): 0: 583: 18.68		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		568557 EPHA2_HUMAN (3-819): 0: 583: 18.68		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		665243 EPHA2_HUMAN (3-819): 0: 583: 18.68		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02
+	Hs
		384267 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		KAPCB_HUMAN (409-714): 3.04e-116: 355: 29.15