HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18022941, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0008543 - fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 593
+	Hs
		601501 FGFR2_HUMAN (1-821): 0: 803: 71.21		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		601466 FGFR2_HUMAN (1-821): 0: 803: 71.21		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		609260 FGFR3_HUMAN (6-821): 0: 730: 61.22		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		507980 FGFR1_HUMAN (1-822): 0: 861: 100.00		PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76
+	Hs
		607949 FGFR4_HUMAN (29-808): 0: 664: 55.60		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		508134 FGFR1_HUMAN (1-822): 0: 861: 100.00		PTPR2_HUMAN (135-531): 5.92e-113: 362: 30.15
+	Hs
		872429 EPHA5_HUMAN (3-791): 0: 639: 19.15		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		985961 EPHA7_HUMAN (3-783): 0: 629: 19.40		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		872635 EPHA4_HUMAN (3-783): 0: 620: 19.44		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		507839 FGFR1_HUMAN (1-822): 0: 861: 100.00		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		607888 FGFR4_HUMAN (29-808): 0: 664: 55.60		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665220 EPHA2_HUMAN (3-819): 0: 583: 18.68		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		546284 NTRK2_MOUSE (111-762): 1.43e-163: 497: 23.74		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		985963 NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Rn
		783507 NTRK2_RAT (111-762): 4.27e-163: 496: 23.89		PTN11_RAT (1-593): 0: 578: 98.99
+	Hs
		616944 EPHA8_HUMAN (3-819): 0: 603: 19.35		PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76
+	Hs
		573629 EPHA5_HUMAN (3-791): 0: 639: 19.15		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		573583 EPHA8_HUMAN (3-819): 0: 603: 19.35		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		573718 NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		573716 NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63