HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: SHE (Q5VZ18)
SH2 domain-containing adapter protein E
Gene: SHE

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	12181353
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 495
+	Hs
		208983 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK2_HUMAN (83-492): 2.07e-61: 207: 15.98
+	Hs
		507832 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK1_HUMAN (83-490): 8.88e-60: 203: 14.60
+	Hs
		508019 FGFR1_HUMAN (1-822): 0: 861: 100.00		SHB_HUMAN (126-490): 1.29e-51: 184: 35.71
+	Hs
		507999 FGFR1_HUMAN (1-822): 0: 861: 100.00		GRB14_HUMAN (181-492): 1.06e-46: 172: 13.81
+	Hs
		507872 FGFR1_HUMAN (1-822): 0: 861: 100.00		SHC1_HUMAN (200-494): 1.12e-45: 170: 16.84
+	Hs
		433229 FGFR1_HUMAN (1-822): 0: 861: 100.00		YES_HUMAN (227-485): 7.02e-45: 167: 13.53
+	Hs
		508060 FGFR1_HUMAN (1-822): 0: 861: 100.00		TENS2_HUMAN (61-478): 4e-43: 165: 15.24
+	Hs
		507818 FGFR1_HUMAN (1-822): 0: 861: 100.00		SRC_HUMAN (224-485): 1.51e-43: 163: 16.91
+	Hs
		507897 FGFR1_HUMAN (1-822): 0: 861: 100.00		ABL2_HUMAN (243-473): 5.51e-35: 141: 19.61
+	Hs
		129184 FGFR1_HUMAN (1-822): 0: 861: 100.00		P85B_HUMAN (174-492): 3.28e-27: 117: 16.21
+	Hs
		507870 FGFR1_HUMAN (1-822): 0: 861: 100.00		P85A_HUMAN (359-492): 4.16e-27: 117: 24.27
+	Hs
		601467 FGFR2_HUMAN (1-821): 0: 803: 71.21		SHC1_HUMAN (200-494): 1.12e-45: 170: 16.84
+	Hs
		412008 FGFR2_HUMAN (1-821): 0: 803: 71.21		FYN_HUMAN (331-492): 2.49e-44: 165: 14.79
+	Hs
		522773 FGFR2_HUMAN (1-821): 0: 803: 71.21		SRC_HUMAN (224-485): 1.51e-43: 163: 16.91
+	Hs
		507850 FGFR1_HUMAN (1-822): 0: 861: 100.00		RASA1_HUMAN (377-490): 3.01e-17: 86.9: 30.25
+	Hs
		147484 FGFR3_HUMAN (6-821): 0: 730: 61.22		SOCS6_HUMAN (62-495): 9.2e-54: 191: 14.57
+	Hs
		129199 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85B_HUMAN (174-492): 3.28e-27: 117: 16.21
+	Hs
		601463 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85A_HUMAN (359-492): 4.16e-27: 117: 24.27
+	Hs
		609182 FGFR3_HUMAN (6-821): 0: 730: 61.22		P85A_HUMAN (359-492): 4.16e-27: 117: 24.27
+	Hs
		129201 FGFR4_HUMAN (29-808): 0: 664: 55.60		P85B_HUMAN (174-492): 3.28e-27: 117: 16.21