HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: KLOTB (Q86Z14)
Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
Gene: KLB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.882

The method score is based on:

Property Details
Experiments 26272615, 17623664, 29648978, 19059246
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Glyco_hydro_1~I-set
Common GO terms GO:0005886 - plasma membrane
GO:0008284 - positive regulation of cell population proliferation
GO:0017134 - fibroblast growth factor binding
GO:0090080 - positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 822
Hs

1 1044
+ Mm
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+ Hs
+ Hs
+ Mm
+ Mm
+ Mm
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+ Mm
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+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024