HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: SH3G1 (Q99961)
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)
Gene: SH3GL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 368
+	Hs
		508089 FGFR1_HUMAN (1-822): 0: 861: 100.00		NOSTN_HUMAN (5-364): 1.09e-39: 149: 17.34
+	Hs
		508265 FGFR1_HUMAN (1-822): 0: 861: 100.00		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Mm
		555266 FGFR1_MOUSE (1-822): 0: 860: 98.42		NOSTN_MOUSE (5-365): 2.04e-32: 129: 16.49
+	Hs
		507939 FGFR1_HUMAN (1-822): 0: 861: 100.00		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		601492 FGFR2_HUMAN (1-821): 0: 803: 71.21		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		608196 FGFR4_HUMAN (29-808): 0: 664: 55.60		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Hs
		609244 FGFR3_HUMAN (6-821): 0: 730: 61.22		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		665683 EPHB2_HUMAN (4-819): 0: 640: 18.07		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Hs
		872506 EPHA5_HUMAN (3-791): 0: 639: 19.15		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Hs
		1072628 EPHA7_HUMAN (3-783): 0: 629: 19.40		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Hs
		608105 FGFR4_HUMAN (29-808): 0: 664: 55.60		SRBS1_HUMAN (235-363): 3.59e-15: 79.2: 25.95
+	Hs
		608026 FGFR4_HUMAN (29-808): 0: 664: 55.60		SH3R1_HUMAN (305-361): 9.5e-13: 71.7: 49.18
+	Hs
		607935 FGFR4_HUMAN (29-808): 0: 664: 55.60		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		665389 EPHA3_HUMAN (3-775): 0: 643: 19.03		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		665574 EPHB2_HUMAN (4-819): 0: 640: 18.07		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Mm
		872621 EPHB2_MOUSE (4-819): 0: 640: 17.95		GRB2_MOUSE (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		872422 EPHA5_HUMAN (3-791): 0: 639: 19.15		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		872610 EPHB1_HUMAN (4-798): 0: 639: 17.57		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		924590 EPHA7_HUMAN (3-783): 0: 629: 19.40		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		872630 EPHA4_HUMAN (3-783): 0: 620: 19.44		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38