HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration GO:0046777 - protein autophosphorylation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 1746
+	Hs
		608132 FGFR4_HUMAN (29-808): 0: 664: 55.60		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		665432 EPHA3_HUMAN (3-775): 0: 643: 19.03		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		665659 EPHB2_HUMAN (4-819): 0: 640: 18.07		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		872489 EPHA5_HUMAN (3-791): 0: 639: 19.15		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1072599 EPHA7_HUMAN (3-783): 0: 629: 19.40		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1083894 NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		385530 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		434286 RET_HUMAN (384-774): 2.63e-98: 332: 45.77		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		507876 FGFR1_HUMAN (1-822): 0: 861: 100.00		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		507838 FGFR1_HUMAN (1-822): 0: 861: 100.00		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		508055 FGFR1_HUMAN (1-822): 0: 861: 100.00		OBSCN_HUMAN (933-1713): 2.16e-56: 220: 11.37
+	Hs
		607895 FGFR4_HUMAN (29-808): 0: 664: 55.60		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		872666 EPHA4_HUMAN (3-783): 0: 620: 19.44		KCC1B_HUMAN (1379-1736): 2.78e-92: 305: 13.97
+	Hs
		665151 EPHA2_HUMAN (3-819): 0: 583: 18.68		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568557 EPHA2_HUMAN (3-819): 0: 583: 18.68		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30