HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: SP100 (P23497)
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)
Gene: SP100

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0019904 - protein domain specific binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 879
+	Hs
		508475 TOP1_HUMAN (1-765): 0: 932: 100.00		SSRP1_HUMAN (642-837): 4.16e-29: 126: 22.57
+	Hs
		508390 TOP1_HUMAN (1-765): 0: 932: 100.00		SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39
+	Hs
		508727 TOP1_HUMAN (1-765): 0: 932: 100.00		HM20A_HUMAN (708-877): 1.67e-26: 113: 20.00
+	Hs
		297453 TOP1_HUMAN (1-765): 0: 932: 100.00		TOX4_HUMAN (765-844): 1.52e-21: 101: 33.75
+	Hs
		996814 TOP1M_HUMAN (183-765): 0: 871: 68.72		SSRP1_HUMAN (642-837): 4.16e-29: 126: 22.57
+	Hs
		617319 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		SP100_HUMAN (1-852): 0: 720: 100.00
+	Hs
		449777 DC2I1_HUMAN (12-216): 5.31e-09: 62: 13.25		HMGB1_HUMAN (675-847): 9.29e-36: 136: 76.30
+	Sc
		388121 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		ABF2_YEAST (753-851): 1.1e-16: 80.8: 25.25
+	Hs
		996715 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		SSRP1_HUMAN (642-837): 4.16e-29: 126: 22.57
+	Hs
		818155 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		SOX2_HUMAN (736-852): 3.75e-28: 117: 15.39