HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	29568061, 34079125, 36089195, 20504901
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 136
+	Hs
		508453 TOP1_HUMAN (1-765): 0: 932: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		508393 TOP1_HUMAN (1-765): 0: 932: 100.00		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Sc
		388119 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Hs
		934881 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952498 DC2I1_HUMAN (12-216): 5.31e-09: 62: 13.25		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		952407 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		828271 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00