HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 20020773
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003677 - DNA binding GO:0003690 - double-stranded DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus and 1 others more... GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 414
+	Hs
		161947 TOP1_HUMAN (1-765): 0: 932: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		508407 TOP1_HUMAN (1-765): 0: 932: 100.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		508516 TOP1_HUMAN (1-765): 0: 932: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Sc
		376565 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		PABP_YEAST (86-269): 2.74e-34: 136: 21.88