HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	28977666, 32744500, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0006338 - chromatin remodeling
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 1912
+	Hs
		1059780 TOP1M_HUMAN (183-765): 0: 871: 68.72		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		508484 TOP1_HUMAN (1-765): 0: 932: 100.00		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Hs
		229291 TOP1_HUMAN (1-765): 0: 932: 100.00		SMCA5_HUMAN (578-1624): 0: 791: 26.01
+	Hs
		508351 TOP1_HUMAN (1-765): 0: 932: 100.00		SMCA1_HUMAN (617-1597): 0: 779: 27.44
+	Dm
		332845 Q9VGW4_DROME (2-215): 1.22e-09: 64.4: 15.04		CHDM_DROME (1-1904): 0: 1364: 50.85
+	Pf
		86920 C6KT30_PLAF7 (2-196): 2.12e-11: 69.8: 16.08		Q8IJG6_PLAF7 (542-1443): 0: 754: 31.15