HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30554943
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006338 - chromatin remodeling
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 726
+	Hs
		508346 TOP1_HUMAN (1-765): 0: 932: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		508772 TOP1_HUMAN (1-765): 0: 932: 100.00		ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21
+	Rn
		1149818 TOP1_RAT (1-765): 0: 922: 96.48		Q6AYL3_RAT (282-556): 1.07e-31: 128: 23.27
+	Hs
		508418 TOP1_HUMAN (1-765): 0: 932: 100.00		BRPF1_HUMAN (20-274): 6.8e-26: 116: 14.94
+	Hs
		243847 TOP1_HUMAN (1-765): 0: 932: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		508596 TOP1_HUMAN (1-765): 0: 932: 100.00		PB1_HUMAN (152-650): 1.14e-18: 93.3: 11.68
+	Hs
		1067060 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		1067006 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		244681 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		244571 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56