HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: DDX42 (Q86XP3)
ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)
Gene: DDX42

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24981860, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 938
+	Hs
		508643 TOP1_HUMAN (1-765): 0: 932: 100.00		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33
+	Hs
		508324 TOP1_HUMAN (1-765): 0: 932: 100.00		DDX5_HUMAN (197-734): 2.1e-147: 452: 35.37
+	Hs
		1154061 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33