HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: PPIL4 (Q8WUA2)
Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4)
Gene: PPIL4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 492
+	Hs
		203495 TOP1_HUMAN (1-765): 0: 932: 100.00		PPIH_HUMAN (9-162): 1.01e-64: 208: 28.22
+	Hs
		508785 TOP1_HUMAN (1-765): 0: 932: 100.00		PPIL1_HUMAN (2-161): 2.44e-63: 205: 36.88
+	Hs
		508652 TOP1_HUMAN (1-765): 0: 932: 100.00		PPWD1_HUMAN (2-156): 3.11e-24: 108: 40.39
+	Hs
		614354 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		PPIB_HUMAN (6-173): 3.15e-58: 193: 34.30