HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: PSPC1 (Q8WXF1)
Paraspeckle component 1 (Paraspeckle protein 1)
Gene: PSPC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001650 - fibrillar center GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 523
+	Hs
		508538 TOP1_HUMAN (1-765): 0: 932: 100.00		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Hs
		508338 TOP1_HUMAN (1-765): 0: 932: 100.00		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Hs
		508548 TOP1_HUMAN (1-765): 0: 932: 100.00		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		508683 TOP1_HUMAN (1-765): 0: 932: 100.00		RBM4B_HUMAN (83-190): 4.07e-09: 60.5: 33.04
+	Hs
		508691 TOP1_HUMAN (1-765): 0: 932: 100.00		RBM4_HUMAN (83-190): 4.98e-09: 60.1: 32.14
+	Sc
		376565 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		PABP_YEAST (4-373): 1.42e-48: 178: 14.85
+	Hs
		1069707 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60