HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: DDX17 (Q92841)
Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72)
Gene: DDX17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	35271311, 15848144
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 729
+	Hs
		508324 TOP1_HUMAN (1-765): 0: 932: 100.00		DDX5_HUMAN (82-715): 6.38e-164: 487: 66.41
+	Hs
		508604 TOP1_HUMAN (1-765): 0: 932: 100.00		DDX42_HUMAN (17-686): 2.46e-144: 447: 31.87
+	Hs
		1154061 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		DDX17_HUMAN (1-717): 0: 626: 100.00