HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: SKI8 (Q9GZS3)
Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]
Gene: SKIC8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 305
+	Hs
		508647 TOP1_HUMAN (1-765): 0: 932: 100.00		FBXW7_HUMAN (91-303): 1.6e-63: 214: 24.30
+	Hs
		508656 TOP1_HUMAN (1-765): 0: 932: 100.00		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		209387 TOP1_HUMAN (1-765): 0: 932: 100.00		PLRG1_HUMAN (4-217): 2.47e-43: 156: 22.52
+	Hs
		196949 TOP1_HUMAN (1-765): 0: 932: 100.00		PRP4_HUMAN (218-304): 3.86e-14: 74.2: 13.68