HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: HM20A (Q9NP66)
High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)
Gene: HMG20A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 347
+	Hs
		508475 TOP1_HUMAN (1-765): 0: 932: 100.00		SSRP1_HUMAN (1-266): 7.41e-32: 128: 16.30
+	Hs
		508390 TOP1_HUMAN (1-765): 0: 932: 100.00		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Hs
		297453 TOP1_HUMAN (1-765): 0: 932: 100.00		TOX4_HUMAN (4-265): 3.04e-29: 120: 15.99
+	Hs
		996814 TOP1M_HUMAN (183-765): 0: 871: 68.72		SSRP1_HUMAN (1-266): 7.41e-32: 128: 16.30
+	Hs
		1246354 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		CIC_HUMAN (27-227): 1.8e-32: 130: 17.24
+	Hs
		996715 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		SSRP1_HUMAN (1-266): 7.41e-32: 128: 16.30
+	Hs
		818155 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Hs
		449777 DC2I1_HUMAN (12-216): 5.31e-09: 62: 13.25		HMGB1_HUMAN (97-265): 2.13e-15: 76.2: 19.65