HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: BRD7 (Q9NPI1)
Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)
Gene: BRD7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	30940648, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 651
+	Hs
		508418 TOP1_HUMAN (1-765): 0: 932: 100.00		BRPF1_HUMAN (4-406): 3.3e-56: 208: 19.24
+	Hs
		508346 TOP1_HUMAN (1-765): 0: 932: 100.00		BRD2_HUMAN (115-424): 3.01e-33: 138: 15.39
+	Rn
		1149818 TOP1_RAT (1-765): 0: 922: 96.48		Q6AYL3_RAT (2-182): 5.37e-20: 93.7: 12.90
+	Hs
		1246372 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		BRD7_HUMAN (1-651): 1.84e-168: 498: 100.00