HitPredict

Interactor 1: FSD2 (A1L4K1)
Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1)
Gene: FSD2

Interactor 2: TRI18 (O15344)
E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)
Gene: MID1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	fn3~fn3, SPRY~SPRY
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 749 Hs			1 667
+	Hs
		50986 FSD2_HUMAN (12-749): 0: 555: 100.00		TRIM1_HUMAN (1-665): 4.96e-164: 490: 72.81
+	Hs
		175623 TRI18_HUMAN (62-747): 5.24e-84: 281: 17.71		TRI18_HUMAN (1-667): 1.27e-180: 530: 100.00
+	Hs
		175727 TRI18_HUMAN (62-747): 5.24e-84: 281: 17.71		TRIM1_HUMAN (1-665): 4.96e-164: 490: 72.81
+	Hs
		1317480 TRI54_HUMAN (147-374): 3.28e-75: 249: 24.78		TRIM1_HUMAN (1-665): 4.96e-164: 490: 72.81
+	Hs
		1232418 CMYA5_HUMAN (47-748): 1.36e-113: 381: 29.03		CMYA5_HUMAN (160-661): 1.55e-72: 258: 19.63
+	Hs
		1190459 TRI46_HUMAN (80-747): 2.48e-79: 271: 13.64		TRIM9_HUMAN (1-659): 6.49e-114: 359: 23.84
+	Hs
		1318677 TRIM9_HUMAN (96-744): 1.27e-71: 249: 18.24		TRIM9_HUMAN (1-659): 6.49e-114: 359: 23.84
+	Mm
		1174367 CMYA5_MOUSE (47-748): 1.01e-107: 363: 28.59		CMYA5_MOUSE (152-661): 4.63e-68: 244: 19.09
+	Mm
		1119764 TRIM9_MOUSE (96-736): 6.48e-83: 282: 19.47		TRI67_MOUSE (54-660): 8.17e-93: 305: 23.77
+	Hs
		175691 TRI18_HUMAN (62-747): 5.24e-84: 281: 17.71		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Hs
		1170591 TRI46_HUMAN (80-747): 2.48e-79: 271: 13.64		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Hs
		1171601 TRIM9_HUMAN (96-744): 1.27e-71: 249: 18.24		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Hs
		1282031 TRI54_HUMAN (147-374): 3.28e-75: 249: 24.78		TRI63_HUMAN (1-380): 2.91e-86: 276: 24.09
+	Hs
		1317433 TRI54_HUMAN (147-374): 3.28e-75: 249: 24.78		TRI54_HUMAN (1-380): 7.45e-80: 259: 22.80
+	Hs
		1318345 TRIM9_HUMAN (96-744): 1.27e-71: 249: 18.24		TRIM8_HUMAN (4-405): 5.33e-72: 244: 20.10
+	Hs
		1237109 TRI54_HUMAN (147-374): 3.28e-75: 249: 24.78		TRIMM_HUMAN (157-667): 5.98e-72: 241: 15.34
+	Hs
		175635 TRI18_HUMAN (62-747): 5.24e-84: 281: 17.71		TRI27_HUMAN (90-433): 1.46e-30: 128: 14.08
+	Hs
		537047 TRIM9_HUMAN (96-744): 1.27e-71: 249: 18.24		TRI27_HUMAN (90-433): 1.46e-30: 128: 14.08
+	Hs
		1203449 TRI54_HUMAN (147-374): 3.28e-75: 249: 24.78		TRI69_HUMAN (99-341): 4.28e-17: 86.7: 14.17