HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: LSM4 (Q9Y4Z0)
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)
Gene: LSM4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	35271311, 12549820
Identification Methods	affinity chromatography technology, unspecified method, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 139
+	Hs
		508784 TOP1_HUMAN (1-765): 0: 932: 100.00		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		508432 TOP1_HUMAN (1-765): 0: 932: 100.00		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Hs
		508429 TOP1_HUMAN (1-765): 0: 932: 100.00		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82