HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: H2A1C (Q93077)
Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)
Gene: H2AC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046982 - protein heterodimerization activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 130
+	Hs
		391523 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		509102 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2A1J_HUMAN (1-128): 5.32e-67: 200: 97.66
+	Hs
		509051 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2A2B_HUMAN (1-130): 3.14e-66: 198: 95.39
+	Hs
		509017 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2A2C_HUMAN (1-130): 5.75e-65: 194: 96.92
+	Hs
		508808 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Zm
		44737 A0A1D6Q7T3_MAIZE (9-1479): 0: 1400: 43.38		B4FMH5_MAIZE (6-129): 6.64e-62: 188: 73.39
+	Sc
		392244 TOP2_YEAST (24-1404): 0: 1262: 41.63		H2A2_YEAST (16-128): 3.45e-59: 180: 81.42