HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: H2B1L (Q99880)
Histone H2B type 1-L (Histone H2B.c) (H2B/c)
Gene: H2BC13

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046982 - protein heterodimerization activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 126
+	Hs
		509018 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B2E_HUMAN (1-126): 2.16e-54: 168: 97.62
+	Hs
		509080 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1H_HUMAN (1-126): 2.44e-54: 168: 97.62
+	Hs
		241433 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1K_HUMAN (1-126): 4.5e-54: 167: 97.62
+	Hs
		420797 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1J_HUMAN (1-126): 2.66e-54: 167: 96.83
+	Hs
		508918 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1C_HUMAN (1-126): 4.4e-54: 167: 98.41
+	Hs
		508891 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1D_HUMAN (1-126): 1.27e-53: 166: 97.62
+	Hs
		973343 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H2B2E_HUMAN (1-126): 2.16e-54: 168: 97.62
+	Hs
		241507 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H2B1K_HUMAN (1-126): 4.5e-54: 167: 97.62
+	Hs
		918302 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H2B1C_HUMAN (1-126): 4.4e-54: 167: 98.41
+	Sc
		355737 TOP2_YEAST (24-1404): 0: 1262: 41.63		H2B2_YEAST (5-125): 1.24e-35: 120: 71.90