HitPredict

Interactor 1: DA (P11420)
Protein daughterless
Gene: DA

Interactor 2: ESMB (Q01069)
Enhancer of split mbeta protein (E(spl)mbeta) (HLH-mbeta) (Split locus enhancer protein mA)
Gene: E(spl)mbeta-HLH

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.768

Property	Details
Experiments	22949507, 9371806
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0043565 - sequence-specific DNA binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 710 Dm			1 195
+	Dm
		509368 DA_DROME (1-710): 0: 908: 100.00		ESMC_DROME (6-195): 3.24e-52: 168: 50.00
+	Dm
		1099427 Q86PA6_DROME (1-697): 0: 912: 96.84		DPN_DROME (9-188): 3.76e-47: 161: 26.67
+	Dm
		509354 DA_DROME (1-710): 0: 908: 100.00		ESM8_DROME (7-195): 1.39e-51: 165: 35.45
+	Dm
		509371 DA_DROME (1-710): 0: 908: 100.00		DPN_DROME (9-188): 3.76e-47: 161: 26.67
+	Dm
		509353 DA_DROME (1-710): 0: 908: 100.00		ESM7_DROME (1-195): 1.93e-48: 157: 44.55
+	Dm
		509352 DA_DROME (1-710): 0: 908: 100.00		ESM5_DROME (8-195): 9.82e-42: 140: 31.58
+	Hs
		146451 TFE2_HUMAN (219-663): 2.17e-109: 347: 31.77		BHE40_HUMAN (6-190): 6.01e-43: 150: 25.65
+	Mm
		550248 TFE2_MOUSE (219-663): 1.94e-102: 329: 31.33		BHE41_MOUSE (5-190): 5.69e-37: 134: 25.65