HitPredict

Interactor 1: UBL4A (P11441)
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX)
Gene: UBL4A

Interactor 2: AMFR (Q9UKV5)
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Gene: AMFR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	24424410, 21636303
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CUE~ubiquitin, ubiquitin~zf-RING_2
Common GO terms	GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016020 - membrane GO:0051087 - protein-folding chaperone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 157 Hs			1 643
+	Hs
		924212 RS27A_HUMAN (1-123): 2.9e-40: 134: 28.46		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Mm
		477046 UBC_MOUSE (1-102): 1.77e-28: 111: 31.13		AMFR_MOUSE (1-643): 0: 604: 94.40
+	Hs
		476551 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		476224 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		RN145_HUMAN (72-428): 1.7e-63: 224: 17.25
+	Rn
		1140402 UBC_RAT (1-102): 9.46e-29: 112: 31.13		MGRN1_RAT (303-626): 9.5e-49: 180: 16.92
+	Sc
		477469 UBI4P_YEAST (1-76): 6.18e-27: 105: 39.47		HRD1_YEAST (73-500): 2.2e-47: 177: 14.54
+	Hs
		610336 RS27A_HUMAN (1-123): 2.9e-40: 134: 28.46		CBL_HUMAN (293-550): 4.72e-35: 143: 19.37
+	Mm
		924236 RS27A_MOUSE (1-123): 2.97e-40: 134: 28.46		RO52_MOUSE (337-629): 2.11e-32: 132: 14.97
+	Rn
		88778 UBC_RAT (1-102): 9.46e-29: 112: 31.13		D3ZV15_RAT (293-550): 7.57e-37: 149: 19.55
+	Hs
		475339 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		CBL_HUMAN (293-550): 4.72e-35: 143: 19.37
+	Hs
		610337 RL40_HUMAN (1-72): 8.53e-30: 106: 41.67		CBL_HUMAN (293-550): 4.72e-35: 143: 19.37
+	Mm
		476831 UBC_MOUSE (1-102): 1.77e-28: 111: 31.13		RO52_MOUSE (337-629): 2.11e-32: 132: 14.97
+	Mm
		476671 UBB_MOUSE (1-76): 9.53e-29: 109: 39.47		RO52_MOUSE (337-629): 2.11e-32: 132: 14.97
+	Mm
		924253 RL40_MOUSE (1-72): 8.53e-30: 106: 41.67		RO52_MOUSE (337-629): 2.11e-32: 132: 14.97
+	Hs
		476254 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		RING2_HUMAN (315-579): 7.78e-32: 128: 14.44
+	Mm
		476994 UBC_MOUSE (1-102): 1.77e-28: 111: 31.13		RN115_MOUSE (316-401): 6.53e-25: 107: 28.89
+	Hs
		476628 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		RN115_HUMAN (316-401): 6.66e-25: 107: 26.67
+	At
		1091813 UBQ3_ARATH (1-77): 2.19e-28: 107: 37.66		RNG1L_ARATH (289-428): 2.87e-24: 106: 20.69
+	Mm
		476947 UBC_MOUSE (1-102): 1.77e-28: 111: 31.13		RN126_MOUSE (318-389): 3.43e-10: 63.7: 32.90
+	Hs
		475842 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		RN151_HUMAN (336-382): 6.08e-10: 62.1: 31.92