HitPredict

Interactor 1: VDR (P11473)
Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)
Gene: VDR

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15604093, 9831079
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 406
+	Hs
		907028 NR1I3_HUMAN (17-421): 5.58e-108: 324: 33.66		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		823807 NR2C2_HUMAN (16-427): 7.44e-97: 303: 19.71		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369311 ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907008 NR1H3_HUMAN (2-425): 7.16e-95: 294: 29.60		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Rn
		411261 ESR1_RAT (2-425): 2.99e-92: 292: 21.20		PRS8_RAT (1-406): 1.42e-136: 398: 100.00
+	Hs
		587150 RXRA_HUMAN (1-424): 3.6e-93: 290: 18.27		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		906997 PPARD_HUMAN (19-424): 2.02e-93: 290: 24.88		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		798664 NR1I3_HUMAN (17-421): 5.58e-108: 324: 33.66		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		823806 NR2C2_HUMAN (16-427): 7.44e-97: 303: 19.71		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		500362 RARB_HUMAN (4-424): 1.61e-91: 285: 22.12		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Mm
		193210 NR1I3_MOUSE (4-421): 3.85e-107: 322: 34.21		PRS6B_MOUSE (1-399): 8.58e-122: 360: 41.86
+	Hs
		906980 ERR3_HUMAN (10-426): 7.59e-91: 284: 21.10		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		740491 PPARG_HUMAN (11-424): 5.91e-96: 298: 25.60		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		369310 ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		798611 NR2C2_HUMAN (16-427): 7.44e-97: 303: 19.71		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		369145 ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		730213 NR2C2_HUMAN (16-427): 7.44e-97: 303: 19.71		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		369100 ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		823822 NR2C2_HUMAN (16-427): 7.44e-97: 303: 19.71		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	Hs
		369327 ESR1_HUMAN (2-425): 4.59e-94: 296: 20.74		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64