HitPredict

Interactor 1: ERR1 (P11474)
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
Gene: ESRRA

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	15604093
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 406
+	Hs
		587150 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		906980 ERR3_HUMAN (25-422): 2.3e-119: 357: 59.30		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		500362 RARB_HUMAN (8-419): 2.41e-114: 344: 25.00		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369311 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Rn
		411261 ESR1_RAT (5-420): 4.56e-109: 335: 33.63		PRS8_RAT (1-406): 1.42e-136: 398: 100.00
+	Hs
		487934 RARA_HUMAN (8-419): 7.07e-111: 335: 25.24		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369310 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		611412 NR4A1_HUMAN (3-422): 2.87e-104: 322: 29.95		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907008 NR1H3_HUMAN (2-417): 1.47e-105: 321: 24.59		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		530791 RARG_HUMAN (20-419): 1.27e-104: 318: 27.43		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907027 HNF4G_HUMAN (71-418): 3.05e-105: 318: 27.59		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907111 ESR2_HUMAN (4-420): 1.27e-100: 311: 33.11		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369145 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		611411 NR4A1_HUMAN (3-422): 2.87e-104: 322: 29.95		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		906889 ESR2_HUMAN (4-420): 1.27e-100: 311: 33.11		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		369100 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		798727 ESR2_HUMAN (4-420): 1.27e-100: 311: 33.11		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		730322 ESR2_HUMAN (4-420): 1.27e-100: 311: 33.11		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		369327 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	Hs
		913328 ESR2_HUMAN (4-420): 1.27e-100: 311: 33.11		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64